16th International Workshop on Osteoarthritis Imaging 
New Insights on Treatment and Imaging:
A Couple that Belongs Together

Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University (TMDU)

Chairs

Nobutake Ozeki, MD, PhD (Tokyo Medical and Dental University)

Ichiro Sekiya, MD, PhD (Tokyo Medical and Dental University)

Scientific Committee

Rianne van der Heijden, MD, PhD (Rotterdam, The Netherlands)

Andy Wong, PhD (Toronto, Canada)

Daichi Hayashi, MD, PhD (New York, NY/USA)

Xiaojuan Li, PhD (Cleveland, OH/USA)

Neil Segal, MD (Kansas City, KS/USA)

Nakagawa Yusuke, MD, PhD (Tokyo, Japan)

Changhai Ding, MD, PhD (Zhujiang, China)

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Local Organizers

Muneaki Ishijima, Professor, Department of Orthopaedic Surgery, Juntendo University Hospital

Mamoru Niitsu, Professor, Department of Radiology, Saitama Medical University

Naoshi Fukui, Professor, Department of Life Sciences, University of Tokyo

Atsuya Watanabe, Visiting Professor, Department of Orthopaedic Surgery, Chiba University

This workshop in Tokyo, Japan's political center since 1603 and a fascinating city with both a rich history and modern culture, will bring together the world's leading stakeholders in the field of osteoarthritis imaging. During four days of plenary sessions mixed with ample opportunities for informal interactions, attendees will be updated about latest scientific results and have the chance to engage in discussions on current challenges and priorities for future research. Since there will be participation of fundamental and clinical researchers, clinicians and industry representatives working with different imaging modalities, this workshop will cover a wide variety of topics spanning the range from technical development, validation, clinical application, image analysis, as well as industry and patient perspectives.

Program

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Day 1
Wednesday, July 6

All times are Tokyo time (GMT+9)

13:00-13:30

Opening: Ichiro Sekiya & Nobutake Ozeki (Chairs of the meeting) 

 

13:30-15:00

Session 1: “Machine Learning/Segmentation”

13:30-14:00

 Keynote speakers: 

Jan Fritz -  Automated segmentation, pattern recognition, risk prediction or image acceleration – which one of these is most promising and will really move OA imaging research forward?

Jamie Collins -  Prediction of progression – Do we need to understand the images or are black-box approaches superior?
Moderator:
Valentina Pedoia

14:00 – 15:00

Oral Presentations:

Michael Mendoza -  Nodestudio, a visual programming framework for musculoskeletal MRI analysis

Anna Wisser – Agreement and sensitivity between-group differences of U-net-based, automated cartilage T2 analyses. Data from the OA-BIO project

Susanne Maschek – Do automated, U-net-based cartilage segmentation from MRI benefit from manual quality control and correction? Data from the IMI-APPROACH project

Shen Liu – Comparison of various metrics for evaluating the performance of deep learning binary classification, particularly when underlying imaging data are imbalanced

15:00 – 15:30

Break & social gathering

15:30-17:15

Session 2: “Is there still a place for radiography in OA research?”

15:30 – 16:15

Keynote speakers:

Haruka Kaneko: Osteophyte

Takuaki Yamamoto: Insufficiency fracture

Noriko Yoshimura: 10-year follow-up of the ROAD study

Moderator: John Carrino


16:15 – 17:15

Oral Presentations:

Mylene Jansen – Joint repair evaluated automatically on radiographs is associated with pain and synovial fluid marker changes after knee joint distraction treatment

Neil Segal – Comparison of concurrent validity of change in 3D JSW on weight-bearing CT vs. 2D JSW on radiographs for cartilage structural worsening over 24 months

Wolfgang Wirth – Predictors of longitudinal MRI-based cartilage thickness change in the observational multicenter APPROACH cohort

Ali Guermazi – Intra-articular knee injection technical success rate. Comparison between ultrasound- and palpation-guided injection using a radiographic depiction of intra-articular air as a reference standard

17:15-17:30

Acknowledgements of Young Investigator Award winners

3 best abstracts

17:30-17:45

IWOAI/ISOAI businesses

Ali Guermazi, President, ISOAI 

Frank Roemer, Editor-in-Chief, Osteoarthritis Imaging

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Day 2
Thursday July 7

09:00 - 10:30

Session 3: “Early OA”

09:00 - 09:45

Keynote speaker:

Muneaki Ishijima: In what order does osteoarthritis of the knee develop?

Moderators: Neil Segal & Atsuya Watanabe

09:45 – 10.30

Oral Presentations:

Mitra Daneshmand – Prediction of osteophyte progression from clinical data and MRI-based 3D knee morphology

Netanja Harlianto – T2 mapping of the articular cartilage as a biomarker for OA in a population-based cohort. The Rotterdam study

Bahram Mohajer – Is comorbid diabetes associated with thigh muscle degeneration and OA progression in patients with knee OA? OAI data

10:30 – 11.00

Break

11:00-12:30

Session 4: “MRI and hybrid Imaging” 


11:00 – 11:45

Keynote speaker:

Nobutake Ozeki: Is there a role for MRI in regenerative medicine?

Patrick Omoumi: Compositional MRI or metabolic imaging--Which one is more relevant for OA?

Moderators: Mamoru Niitsu


11:45 – 12:30

Oral Presentations:

Michael Williams – 3-D distribution of bone parameters across the distal femur from weight-bearing CT follow patterns according to joint space narrowing phenotype: A multicenter osteoarthritis study investigation

Sarah Ghobrial – 3-D joint space width from weight-bearing computed tomography is better than 2-D radiographic measures at predicting future lateral joint space narrowing at the knee: A multicenter osteoarthritis study investigation

Alan Brett – Comparison of 3D quantitative osteoarthritis imaging biomarkers: A study using paired CT and MR images from the IMI-APPROACH study

12:30 – 14.00

Lunch 

14:00 – 15:30

Session 5: “Synovium: New Concepts and Treatment

14:00  14:30

Keynote speaker:

Naoshi Fukui

Moderator: Yusuke Nakagawa & Edwin Oei

14:30 – 15:30

Oral Presentations:

Benny Antony – Effect of curcuma longa extract on MRI-based synovitis and serum inflammatory markers in knee osteoarthritis: secondary analyses from CURKOA trial

Arjun Vohra – Reliability and validity of single axial slice vs. multiple slice quantitative measurement of knee effusion-synovitis on 3T MRI

Siwen Liu – Bone-muscle-fat interactions and perfusive evidence of in non-overweight postmenopausal women with early knee OA

Frank Roemer – Non-chondral multi-tissue pathology as assessed by MRI increases rates of quantitative MRI-defined cartilage thickness loss over 24 months: The APPROACH study

15:30 - 16:00

Break

16:00-17:30

Session 6: “NGF, Corticosteroids and meniscus Treatments”    

Keynote speaker:

Kent Kwoh: NGF

Ali Guermazi: Corticosteroids

Hideyuki Koga: Meniscus centralization

Moderator: Daichi Hayashi


17:30 – 18:00

Poster session

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Day 3
Friday July 8

9:00-10:15

Session 7: “Orthobiologics”


9:00 – 9:45

Keynote speakers: 

Ayano Kuwasawa: PRP

David Hunter: PRP: Results of an RCT

Norimasa Nakamura: MSCs

Moderators: Shadpour Demehri & Muneaki Ishijima

9:45 – 10:15

Oral Presentations:

Bahram Mohajer – Statin use is associated with subtle changes in muscle composition and quality: A quantitative imaging analysis using OAI data

Mohamed Jarraya – Prevalence of potential MRI-based exclusionary findings in osteoarthritis clinical trials: Data from the Osteoarthritis Initiative (OAI)

10:15 - 10:45

Break

10:45-12:15

Session 8: “Meniscus and OA”


10:45 – 11:15

Keynote speaker

Ichiro Sekiya: Is the meniscal injury a cause or a consequence in osteoarthritis?

Moderators: Neil Segal


11:15 - 12:15

Oral Presentations:

Jan Van der Voet – Is postmenopausal status associated with increased risk for meniscus extrusion?

Jeffrey Duryea – Comparison between BML volumes from a semi-automated software method and BML volumes from a deep learning algorithm: Data from the Osteoarthritis Initiative (OAI)

Rafael Heiss – Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with Kellgren-Lawrence grades and meniscal extrusion

Jason Tsang – Higher intra-muscular fat within knee extensor and adductor muscles predicts more painful and progressive osteoarthritis

12:15 – 13:00

Poster session

13:00 - 14:00

Lunch

14:00-15:45

Session 9: Patellofemoral OA


14:00 – 15:00

Keynote speakers:

Shadpour Demehri: Imaging

Simo Saarakkala: Machine learning

Changhai Ding: How different OA is in Asia

Ken Kumagai: PFOA in Japanese females

Moderators: Wolfgang Wirth & Norimasa Nakamura


15:00 – 15:45

Oral Presentations:

Banafshe Felfeliyan – Automatic effusion measurement with limited labelled data

Hisako Katano – Morphological analysis of 3D MRI images of PF joints in asymptomatic subjects

Jos Runhaar – MRI defined OA as an outcome measure for an osteoarthritis prevention study: Practical implications and feasibility.


15:45 – 16:15

Break

16:15-17:15

Session 10: “Which DMOAD treatment approaches are likely the most promising: Status 2022.”

Panel presentations: Marc Hochberg, Philip Conaghan
Industry: Sungsu Han, Didier Laurent
Moderators: David Hunter

17:15-17:46

Adjourn and an invitation to IWOAI 2023: 

Patrick Omoumi & Julien Favre (Lausanne/Switzerland)

18:30 - 21:00

Gala dinner

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Day 4
Saturday July 9

 

9.00 – 16:00

Exploring the history of the Tokyo area