.jpg)
16th International Workshop on Osteoarthritis Imaging
New Insights on Treatment and Imaging:
A Couple that Belongs Together
Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University (TMDU)
Chairs
Nobutake Ozeki, MD, PhD (Tokyo Medical and Dental University)
Ichiro Sekiya, MD, PhD (Tokyo Medical and Dental University)
Scientific Committee
Rianne van der Heijden, MD, PhD (Rotterdam, The Netherlands)
Andy Wong, PhD (Toronto, Canada)
Daichi Hayashi, MD, PhD (New York, NY/USA)
Xiaojuan Li, PhD (Cleveland, OH/USA)
Neil Segal, MD (Kansas City, KS/USA)
Nakagawa Yusuke, MD, PhD (Tokyo, Japan)
Changhai Ding, MD, PhD (Zhujiang, China)
Local Organizers
Muneaki Ishijima, Professor, Department of Orthopaedic Surgery, Juntendo University Hospital
Mamoru Niitsu, Professor, Department of Radiology, Saitama Medical University
Naoshi Fukui, Professor, Department of Life Sciences, University of Tokyo
Atsuya Watanabe, Visiting Professor, Department of Orthopaedic Surgery, Chiba University
This workshop in Tokyo, Japan's political center since 1603 and a fascinating city with both a rich history and modern culture, will bring together the world's leading stakeholders in the field of osteoarthritis imaging. During four days of plenary sessions mixed with ample opportunities for informal interactions, attendees will be updated about latest scientific results and have the chance to engage in discussions on current challenges and priorities for future research. Since there will be participation of fundamental and clinical researchers, clinicians and industry representatives working with different imaging modalities, this workshop will cover a wide variety of topics spanning the range from technical development, validation, clinical application, image analysis, as well as industry and patient perspectives.
Program
Day 1
Wednesday, July 6
All times are Tokyo time (GMT+9)
13:00-13:30
Opening: Ichiro Sekiya & Nobutake Ozeki (Chairs of the meeting)
13:30-15:00
Session 1: “Machine Learning/Segmentation”
13:30-14:00
Keynote speakers:
Jan Fritz - Automated segmentation, pattern recognition, risk prediction or image acceleration – which one of these is most promising and will really move OA imaging research forward?
Jamie Collins - Prediction of progression – Do we need to understand the images or are black-box approaches superior?
Moderator: Valentina Pedoia
14:00 – 15:00
Oral Presentations:
Michael Mendoza - Nodestudio, a visual programming framework for musculoskeletal MRI analysis
Anna Wisser – Agreement and sensitivity between-group differences of U-net-based, automated cartilage T2 analyses. Data from the OA-BIO project
Susanne Maschek – Do automated, U-net-based cartilage segmentation from MRI benefit from manual quality control and correction? Data from the IMI-APPROACH project
Shen Liu – Comparison of various metrics for evaluating the performance of deep learning binary classification, particularly when underlying imaging data are imbalanced
15:00 – 15:30
Break & social gathering
15:30-17:15
Session 2: “Is there still a place for radiography in OA research?”
15:30 – 16:15
Keynote speakers:
Haruka Kaneko: Osteophyte
Takuaki Yamamoto: Insufficiency fracture
Noriko Yoshimura: 10-year follow-up of the ROAD study
Moderator: John Carrino
16:15 – 17:15
Oral Presentations:
Mylene Jansen – Joint repair evaluated automatically on radiographs is associated with pain and synovial fluid marker changes after knee joint distraction treatment
Neil Segal – Comparison of concurrent validity of change in 3D JSW on weight-bearing CT vs. 2D JSW on radiographs for cartilage structural worsening over 24 months
Wolfgang Wirth – Predictors of longitudinal MRI-based cartilage thickness change in the observational multicenter APPROACH cohort
Ali Guermazi – Intra-articular knee injection technical success rate. Comparison between ultrasound- and palpation-guided injection using a radiographic depiction of intra-articular air as a reference standard
17:15-17:30
Acknowledgements of Young Investigator Award winners
3 best abstracts
17:30-17:45
IWOAI/ISOAI businesses
Ali Guermazi, President, ISOAI
Frank Roemer, Editor-in-Chief, Osteoarthritis Imaging
Day 2
Thursday July 7
09:00 - 10:30
Session 3: “Early OA”
09:00 - 09:45
Keynote speaker:
Muneaki Ishijima: In what order does osteoarthritis of the knee develop?
Moderators: Neil Segal & Atsuya Watanabe
09:45 – 10.30
Oral Presentations:
Mitra Daneshmand – Prediction of osteophyte progression from clinical data and MRI-based 3D knee morphology
Netanja Harlianto – T2 mapping of the articular cartilage as a biomarker for OA in a population-based cohort. The Rotterdam study
Bahram Mohajer – Is comorbid diabetes associated with thigh muscle degeneration and OA progression in patients with knee OA? OAI data
10:30 – 11.00
Break
11:00-12:30
Session 4: “MRI and hybrid Imaging”
11:00 – 11:45
Keynote speaker:
Nobutake Ozeki: Is there a role for MRI in regenerative medicine?
Patrick Omoumi: Compositional MRI or metabolic imaging--Which one is more relevant for OA?
Moderators: Mamoru Niitsu
11:45 – 12:30
Oral Presentations:
Michael Williams – 3-D distribution of bone parameters across the distal femur from weight-bearing CT follow patterns according to joint space narrowing phenotype: A multicenter osteoarthritis study investigation
Sarah Ghobrial – 3-D joint space width from weight-bearing computed tomography is better than 2-D radiographic measures at predicting future lateral joint space narrowing at the knee: A multicenter osteoarthritis study investigation
Alan Brett – Comparison of 3D quantitative osteoarthritis imaging biomarkers: A study using paired CT and MR images from the IMI-APPROACH study
12:30 – 14.00
Lunch
14:00 – 15:30
Session 5: “Synovium: New Concepts and Treatment
14:00 – 14:30
Keynote speaker:
Naoshi Fukui
Moderator: Yusuke Nakagawa & Edwin Oei
14:30 – 15:30
Oral Presentations:
Benny Antony – Effect of curcuma longa extract on MRI-based synovitis and serum inflammatory markers in knee osteoarthritis: secondary analyses from CURKOA trial
Arjun Vohra – Reliability and validity of single axial slice vs. multiple slice quantitative measurement of knee effusion-synovitis on 3T MRI
Siwen Liu – Bone-muscle-fat interactions and perfusive evidence of in non-overweight postmenopausal women with early knee OA
Frank Roemer – Non-chondral multi-tissue pathology as assessed by MRI increases rates of quantitative MRI-defined cartilage thickness loss over 24 months: The APPROACH study
15:30 - 16:00
Break
16:00-17:30
Session 6: “NGF, Corticosteroids and meniscus Treatments”
Keynote speaker:
Kent Kwoh: NGF
Ali Guermazi: Corticosteroids
Hideyuki Koga: Meniscus centralization
Moderator: Daichi Hayashi
17:30 – 18:00
Poster session
Day 3
Friday July 8
9:00-10:15
Session 7: “Orthobiologics”
9:00 – 9:45
Keynote speakers:
Ayano Kuwasawa: PRP
David Hunter: PRP: Results of an RCT
Norimasa Nakamura: MSCs
Moderators: Shadpour Demehri & Muneaki Ishijima
9:45 – 10:15
Oral Presentations:
Bahram Mohajer – Statin use is associated with subtle changes in muscle composition and quality: A quantitative imaging analysis using OAI data
Mohamed Jarraya – Prevalence of potential MRI-based exclusionary findings in osteoarthritis clinical trials: Data from the Osteoarthritis Initiative (OAI)
10:15 - 10:45
Break
10:45-12:15
Session 8: “Meniscus and OA”
10:45 – 11:15
Keynote speaker:
Ichiro Sekiya: Is the meniscal injury a cause or a consequence in osteoarthritis?
Moderators: Neil Segal
11:15 - 12:15
Oral Presentations:
Jan Van der Voet – Is postmenopausal status associated with increased risk for meniscus extrusion?
Jeffrey Duryea – Comparison between BML volumes from a semi-automated software method and BML volumes from a deep learning algorithm: Data from the Osteoarthritis Initiative (OAI)
Rafael Heiss – Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with Kellgren-Lawrence grades and meniscal extrusion
Jason Tsang – Higher intra-muscular fat within knee extensor and adductor muscles predicts more painful and progressive osteoarthritis
12:15 – 13:00
Poster session
13:00 - 14:00
Lunch
14:00-15:45
Session 9: Patellofemoral OA
14:00 – 15:00
Keynote speakers:
Shadpour Demehri: Imaging
Simo Saarakkala: Machine learning
Changhai Ding: How different OA is in Asia
Ken Kumagai: PFOA in Japanese females
Moderators: Wolfgang Wirth & Norimasa Nakamura
15:00 – 15:45
Oral Presentations:
Banafshe Felfeliyan – Automatic effusion measurement with limited labelled data
Hisako Katano – Morphological analysis of 3D MRI images of PF joints in asymptomatic subjects
Jos Runhaar – MRI defined OA as an outcome measure for an osteoarthritis prevention study: Practical implications and feasibility.
15:45 – 16:15
Break
16:15-17:15
Session 10: “Which DMOAD treatment approaches are likely the most promising: Status 2022.”
Panel presentations: Marc Hochberg, Philip Conaghan
Industry: Sungsu Han, Didier Laurent
Moderators: David Hunter
17:15-17:46
Adjourn and an invitation to IWOAI 2023:
Patrick Omoumi & Julien Favre (Lausanne/Switzerland)
18:30 - 21:00
Gala dinner
Day 4
Saturday July 9
9.00 – 16:00
Exploring the history of the Tokyo area