15th International Workshop on Osteoarthritis Imaging 

Open Up: The Multifaceted Nature of OA Imaging

Inntel Hotel - Leuvehaven 80, 3011 EA

Rotterdam, Netherlands

Co-Chairs:

Jos Runhaar, PhD

Edwin Oei, MD, PhD

Scientific Committee

Shadpour Demehri, MD

John Lynch, PhD

Emily McWalter, PhD

Sven Nebelung, MD

Valentina Pedoia, PhD

Tom Turmezei, MD

Wolfgang Wirth, PhD

This workshop in the vibrant city of Rotterdam, The Netherlands, will bring together the world's leading stakeholders in the field of osteoarthritis imaging. During four days of plenary sessions mixed with ample opportunities for informal interactions, attendees will be updated about latest scientific results and have the chance to engage in discussions on current challenges and priorities for future research. Since there will be participation of fundamental and clinical researchers, clinicians and industry representatives working with different imaging modalities, this workshop will cover a wide variety of topics spanning the range from technical development, validation, clinical application, image analysis, as well as industry and patient perspectives.  

Program
See COVID Update Here

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Day 1
Wednesday June 30

Pre-Course, Welcoming

All times are Rotterdam time (CET)

13:00-14:00

Lunch at Inntel

 

14:15-14:30

Opening: Edwin Oei & Jos Runhaar (Chairs of the meeting)

 

14:30-16:00

Session 1: Imaging of Early OA; patient selection vs. outcome measures

 

14:30 – 15:00

Keynote speaker: Sita Bierma-Zeinstra

Moderators: Simo Saarakkala and Wolfgang Wirth


15:00 – 16:00

Four abstracts 

Roemer: Kellgren and Laurence grade 2 and 3 knees exhibit heterogeneous spectrum of cartilage damage: The MOST study

Wisser: Association of semiquantitative MRI-based measures of knee cartilage with increased cartilage loss in knees at elevated risk of developing OA – Data from the Osteoarthritis Initiative

Runhaar: Evaluating the tibial spines as imaging biomarker for incident knee OA

Panfilov: Deep learning to predict early radiographic knee OA progression directly from MRI

16:00 – 17:00

Break and social gathering on Gather.Town

17:00 – 18:30

Session 2: “New (MRI) techniques for OA imaging” 


17:00 – 17:30

Keynote speaker: Patrick Omoumi 

Moderators: Jutta Ellerman and Feliks Kogan


17:30 – 18:30

Four abstracts 

Heiss: Compositional MRI of articular cartilage of the wrist at 3T and 7T MRI:

A comparative study of T2 and T2* relaxometry

Einarsson: Pilot imaging ex vivo human meniscus with phase-contrast enhanced synchrotron micro-tomography

Kestila: 3D grading of calcifications from ex vivo human meniscus posterior horn

Egnell: Evaluation of an AI system for knee osteoarthritis

18:30 – 18:40

Acknowledgements of Young Investigator Award Winners

By: Emily McWalter & John Lynch

Jansen: Knee joint distraction results in MRI cartilage thickness increase up to ten years after treatment

Anwari: Knee pain is associated with perfusion kinetics at the infrapatellar fat pad among non-overweight postmenopausal women

Nguyen: Interpretable deep learning framework for knee osteoarthritis structural prognosis prediction

18:40 – 19.00

IWOAI/ISOAI businesses 

Ali Guermazi, ISOAI President

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Day 2
Thursday July 1

08:30 - 10:30

Local Social Outing pending COVID regulations

10:30 - 11:00

Pre-meeting update on Computed Tomography in Osteoarthritis (OCTA)         

Research: Progress Update and Call for Membership

Organizer: Tom Turmezei

11:00 – 12:15

Session 3: “Imaging of pain mechanisms in OA” 


11:00 – 11:30

Keynote speaker: Dorothee Auer

Moderators: David Hunter and Patrick Omoumi


11:30 – 12:15

Three abstracts 

Liu: The relationship between periarticular muscle properties and knee pain in non-overweight post-menopausal women

Guermazi: The role of reader training, calibration and consensus sessions in the centralized, single-read, radiographic assessment paradigm used to determine patient eligibility in three phase III trials of Tanezumab for OA

Carrino: Joint safety subgroup analysis in three phase III studies of Tanezumab

12:15 – 12.30

Poster pitches

12:30 - 13:00

Lunch and social gathering on Gather.Town

13:00 - 14:00

Poster session (odd poster numbers) @Gather.Town

14:00 – 15:00

Session 4: “Knee Osteoarthritis Prediction (KNOAP2020) Challenge” 
 

14:00 - 14:30

Keynote speaker: Jukka Hirvasniemi

Moderator: Stefan Klein

14:30 – 15:00

Presentation by challenge winners:

Cem Deniz: Deep learning for prediction of incident symptomatic knee OA

15:00 - 15:30

Break and social gathering on Gather.Town

15:30 – 17:00

Session 5: “Imaging of bone-cartilage interactions in OA” 


15:30 – 16:00

Keynote speaker: Sharmila Majumdar  

Moderators: Saija Kontulainen & Gun-Il Im

 

16:00 – 17:00

Four abstracts 

Watkins: Areas of altered [18F]NAF PET uptake in response to exercise show OA progression on MRI over 2 years

Liu: Automatic detection of BMLs from knee MRI data from the OAI study

Eijkenboom: 3D patellar shape is associated with radiographic and clinical signs of patellofemoral osteoarthritis

Bayramoglu: Analysis of patellar bone texture for automatic detection of patellofemoral osteoarthritis


17:00 – 17:30

Break and social gethering on Gather.Town 

17:30 – 19:00

Session 6: “Different perspectives on OA imaging” 

3 Keynote speakers:

Patient perspective: Elizabeth Cottrell and John Edwards 
Clinical care perspective: Carl-Johan Tiderius 
Clinical trial perspective: Nancy Lane

Moderators: Margreet Kloppenburg and Thomas Link

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Day 3
Friday July 2

 

9:30 – 10:45

Session 7: “Big Data OA imaging studies” 


9:30 – 10:00

Keynote speaker: Meike Vernooij 

Moderators: Sven Nebelung and Tom Turmezei


10:00 – 10:45

Three abstracts

Wirth: MRI-based semiquantitative assessment (MOAKS) allows target selection of knees with accelerated quantitative cartilage thickness loss: Data from FNIH biomarker consortium

Anwari: Knee pain is associated with perfusion kinetics at the infrapatellar fat pad among non-overweight postmenopausal women

Rondas: The association between hip pain and radiographic hip osteoarthritis in the CHECK cohort

10:45 - 11:15

Break and social gathering on Gather.Town

11:15 – 12:45

Session 8: “Image analysis/Artificial Intelligence in OA imaging” 


11:15 – 11:45

Keynote speaker: Simo Saarakkala 

Moderators: Erik Dam and Mikael Boesen


11:45 - 12:45

Four abstracts

Felfeliyan: Domain adaptation on OAI dataset for unsupervised segmentation of bone and cartilage

Rytky: Application of super-resolution deep learning for clinical cone-beam CT of ankle joint

Nguyen: Interpretable deep learning framework for knee osteoarthritis structural prognosis prediction[EO1] 

Caliva: Virtual bone aging: Can we predict 48 months of bone surface changes?

12:45 – 13:00

Poster pitches

13:00 - 13:30

Lunch and social gathering on Gather.Town

13:30 - 14:30

Poster session (even poster numbers) @Gather.Town

14:30 – 16:00

Session 9: “Integrating biomechanics and imaging in OA” 


14:30 – 15:00

Keynote speaker: Janet Ronsky  

Moderators: James (JD) Johnston and Neil Segal


15:00 – 16:00

Four abstracts

Jansen: Knee joint distraction results in MRI cartilage thickness increase up to ten years after treatment

Bzowey: Focal changes in T2 relaxation time of loaded cadaver femoral cartilage

Nebulung: Functional imaging of cartilage by serial T1ρ mapping - Different loading regimes in the assessment of tissue functionality

Huppertz: Comprehensive serial T2 mapping to evaluate and monitor post-traumatic human cartilage degradation


16:00 – 16:30

Break and social gathering on Gather.Town 

16:30 – 18:00

Session 10: “The ‘open data’ paradigm” 


16:15 – 17:30

Panel presentations: OAI (Kent Kwoh), OA Trial Bank (Stefan Lohmander), 
Industry (Olga Kubassova), Platform developer (Serena Bonaretti), and  
Funding agency (Corné Baatenburg de Jong/Heidi van Vugt; Dutch Arthritis Society, ReumaNederland) 

Moderators: Martin Englund & Frank Roemer


17:30 – 18:00

Panel discussion 

18:00 – 18:30

Adjourn and invitation to IWOAI 2022: Nobutake Ozeki (Tokyo/Japan)

19:30 - 23:00

Gala dinner pending COVID regulations

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Day 4
Saturday July 3

 

9.00 – 20:30

Social event: Sailing day-trip on the Markermeer with visit to historical town Volendam (lunch and dinner included) Pending COVID restrictions.