14th International Workshop on Osteoarthritis Imaging 

Study Designs

Paracelsus Medical University (PMU)

Salzburg, Austria

Chairperson: Felix Eckstein, MD

Scientific Advisory Board

 

Dawn Aitken, PhD
Senior Research Fellow, Menzies Institute for Medical Research,
University of Tasmania, Hobart, Australia

 

Leticia Deveza, MD/PhD
Research Fellow, Department of Rheumatology, Royal North Shore Hospital and Institute of Bone & Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.

 

Thomas Link, MD/PhD
Professor of Radiology, Chief, Musculoskeletal Imaging, Clinical Director Musculoskeletal & Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UCSF School of Medicine, San Francisco, CA, USA

 

Sven Nebelung, MD/PhD
Head, Musculoskeletal Imaging Group, Department of Diagnostic and Interventional Radiology,
Medical Faculty, University of Düsseldorf, Düsseldorf, Germany

 

Anja Niehoff, PhD
Head, Department of Tissue Mechanics & Mechanobiology,
German Sport University Cologne, Köln, Germany

Pharma Industry Advisory Board

 

Henri Deckx, MD
Senior Director, Clinical Development Leader GLPG1972 Galapagos Belgium

 

Markus John, MD

Franchise Head Immunology & Ophthalmology, Global Product Development Medical Affairs (PDMA) Hoffmann-La Roche AG, Basel, Switzerland

Dae-Won Kim, PhD

CEO  & Professor at Yonsei University of Seoul
ICM Co., Ltd., Seoul, Republic of Korea

Chris Ladel, PhD
Director Translational Medicine, Expert Lead
Merck KGaA, Darmstadt, Germany

 

Maria Puyeo, MD/PhD
Project Director, Center for Therapeutic Innovation Immuno-Inflammatory Diseases,Institut de Recherches Internationales Servier, Suresnes, France

 

Christopher Swearingen, PhD
Vice President, Clinical Outcomes and Analytics
Samumed, LLC, San Diego, CA, USA

 

More pending

Focus Topics of the 2020 IWOAI

  • Design of Clinical Trials on Symptom Modification

  • Design of Clinical Trials on Structure Modification (DMOADs)

  • Design of Novel Image Acquisition Approaches

  • Design of Novel Image Segmentation Approaches

  • Mechano-Imaging: Design of Studies on Interaction between Mechanics and Joint Structures

  • Symptom-Imaging: Design of Studies on Interaction between Symptoms and Joint Structures

Program

Day 1
Wednesday September 09

15:30-16:00

Registration & snacks

PMU, Strubergasse 21, Entree House A (Ground Floor)

 

16:00

Welcome

Univ. Prof. Dr. med Wolfgang Sperl; Rector, Paracelsus Medical University

Univ. Prof. Dr. med. Jan Pruszak, Chair, Institute of Anatomy & Cell Biology, Paracelsus Medical University

Univ. Prof. Dr. med. Ali Guermazi, President ISOAI

Univ. Prof. Dr. med. Felix Eckstein, Organizer IWOAI 2020

16:15-17:00

Session 1: Symptom-Imaging         

Invited Lecture: Frank Roemer

Clinical Outcomes & Translation of Structure Modification to Clinical Benefit

17:00-17:30

1-Tobias Hafner: Effects of collagenase exposure on cartilage functionality – A multiparametric quantitative MRI study (SO)

2-Victoria Racher: Dependence of WOMAC pain on radiographic knee OA status, age, sex, body mass index (BMI), race and contralateral knee pain status (SO)

17:30-18:00

Coffee Break

18:00-18:45

Invited Lecture: Dirk Strunk

Stem Cell Therapy - General Principles and Application to Osteoarthritis

19:00

Dinner: TRUMEREI 9Strubergasse 26)

Day 2
Thursday September 10

09:00-09:45

Session 2: Structure Modification

Invited Lecture: Hans Guehring       

Oral Design of Clinical Trials on Structure Modification - Lessons Learned from Sprifermin & Other Programs

9:45-10:45

3-Felix Eckstein: Long-term efficacy and safety of intra-articular Sprifermin in patients with knee osteoarthritis: Results from the 5-year FORWARD study (LO)

4-Henri Deckx: Study design of Roccella: A phase 2 clinical trial with disease-modifying osteoarthritis drug candidate GLPG1972/S201086 (SO)      

5-Frank Roemer: Patterns of structural progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype (SO)

10:45-11:15

Coffee Break

11:15-12:00

Session 3: Image Acquisition

Invited Lecture: Neal Bangerter

Design of Novel Image Acquisition Approaches - Current Experience with 7 Tesla

12:00-13:00

6-Daniel Abrar: Detection of early cartilage degeneration in the tibiotalar joint using 3T GAGCEST imaging: A feasibility study (SO)

7-David Fuerst: Superficial cartilage transverse relaxation time (T2) predicts osteoarthritis disease progression – Data from the FNIH Biomarker study of the OAI (SO)

8- Marloes van Mourik: Accuracy of bone density and morphology measurements obtained from high resolution peripheral quantitative CT scans of the knee (SO)                  

9- Melissa Bevers: The healing of conservatively treated scaphoid fractures assessed by high-resolution peripheral quantitative computed tomography (Poster)

13:00-14:00

Lunch Entree House A (Ground Floor)

14:00-14:45

Session 4: Symptom Modification

Invited Lecture: Christine West     

Design of Clinical Trials on Symptom Modification - Lessons Learned from Anti-NGF Programs

14:45-15:30

10-Frank Roemer: Evolution of MRI-defined structural damage after anterior cruciate ligament injury over 5 years: The Kanon study (LO)

11-Peter Mandl: Tendon involvement and its role in hand function and pain in patients with osteoarthritis of the hand (SO) 

15:30-16:00

Coffee Break

16:00-18:00

Session 5: Poster Viewing (Multifunction-Room Souterrain)

18:30

Dinner: SEMPRE (Strubergasse 28)

Day 3
Friday September 11

 

9:00-09:45

Session 6: Image Segmentation

Invited Lecture: Akshay Chaudhari

Novel Image Segmentation Approaches - Lessons Learned from Deep Learning Designs

9:45-11:00

12-Wolfgang Wirth: A deep learning automated segmentation algorithm accurately detects differences in longitudinal cartilage thickness loss – Data from the FNIH biomarkers study of the OAI (LO)

13-David Fuerst: 3D contour registration reveals that location-independent cartilage thickness scores and regional patterns differ between early and late follow-up after ACL rupture (SO)                       

14-Jana Kemnitz: Automated measurement of local, MRI-based measures of thigh adipose and muscle tissue are highly responsive to bidirectional change in body weight – Data from the OAI (SO)

15-Justus Schock: Artificial intelligence-based automated analysis of alignment in full-leg radiographs (SO)

11:00-11:30

Coffee Break

11:30-12:15

Session 7: Mechano-Imaging

Invited Lecture: Anna-Maria Liphardt

Mechano-Imaging - Imaging Application to Space Flight

12:15-13:15

16-Ali Guermazi: Frequency of osteoarthritis in athletes undergoing MRI at the Olympics in Rio 2016 (LO)

17-Tobias Hafner: Biomechanical Imaging of Proteoglycan-depleted human articular cartilage – A functional MRI study (SO)

18-Rafael Heiss: Effects of sports climbing on cartilage structural composition of the metacarpo-phalangeal and proximal interphalangeal joints as assessed by T2 relaxometry at 7T MRI (SO)

13:15-14:15

Lunch: Entree House A (Ground Floor)

14:15-14:30

Edwin Oei: Invitation to 15th IWOAI 2021 in Rotterdam, The Netherlands

14:30-15:55

Podium Discussion

Drug Development in OA: What are the obstacles?

15:55-16:00

Closing Note: Felix Eckstein & Ali Guermazi

16:00

Drinks: Entree House A & TRUMMEREI

19:00

Dinner: Hangar 7 Bar

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Day 4
Saturday September 12

Tour to the Predigtstuhl (1650m)

9:00

Ride with the Predigtstuhlbahn, Germany’s oldest cable car (1927)
from Bad Reichenhall: https://www.predigtstuhlbahn.de/en/home.
Approx. 15 min walk to the mountain restaurant Schlegelmulde.
Excursion to the Hochschlegel and Karkopf for those motivated to hike. Reunite at Mountain Restaurant Schlegelmulde for lunch. Enjoy the afternoon and take the cable car or walk back down to Bad Reichenhall.

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Day 5
Sunday September 13

Tour to the Watzmann (2650m)

8:00

For those interested in serous hiking, and pending weather, we will offer climbing the Watzmannhaus at 1930 m altitude starting from Berchtes-gaden, potentially also the Watzmann – Hocheck summit at 2650m altitude.

Contact Us

 Address- 601 Albany Street, Ground Floor, Boston, MA 02118, USA

© 2023 by International Society of Osteoarthritis Imaging (ISOAI) Inc. All Rights Reserved.

ISOAI is a registered Non-Profit Organization