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14th International Workshop on Osteoarthritis Imaging
Study Designs
Paracelsus Medical University (PMU)
Salzburg, Austria
Chairperson: Felix Eckstein, MD
Scientific Advisory Board
Dawn Aitken, PhD
Senior Research Fellow, Menzies Institute for Medical Research,
University of Tasmania, Hobart, Australia
Leticia Deveza, MD/PhD
Research Fellow, Department of Rheumatology, Royal North Shore Hospital and Institute of Bone & Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
Thomas Link, MD/PhD
Professor of Radiology, Chief, Musculoskeletal Imaging, Clinical Director Musculoskeletal & Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, UCSF School of Medicine, San Francisco, CA, USA
Sven Nebelung, MD/PhD
Head, Musculoskeletal Imaging Group, Department of Diagnostic and Interventional Radiology,
Medical Faculty, University of Düsseldorf, Düsseldorf, Germany
Anja Niehoff, PhD
Head, Department of Tissue Mechanics & Mechanobiology,
German Sport University Cologne, Köln, Germany
Pharma Industry Advisory Board
Henri Deckx, MD
Senior Director, Clinical Development Leader GLPG1972 Galapagos Belgium
Markus John, MD
Franchise Head Immunology & Ophthalmology, Global Product Development Medical Affairs (PDMA) Hoffmann-La Roche AG, Basel, Switzerland
Dae-Won Kim, PhD
CEO & Professor at Yonsei University of Seoul
ICM Co., Ltd., Seoul, Republic of Korea
Chris Ladel, PhD
Director Translational Medicine, Expert Lead
Merck KGaA, Darmstadt, Germany
Maria Puyeo, MD/PhD
Project Director, Center for Therapeutic Innovation Immuno-Inflammatory Diseases,Institut de Recherches Internationales Servier, Suresnes, France
Christopher Swearingen, PhD
Vice President, Clinical Outcomes and Analytics
Samumed, LLC, San Diego, CA, USA
More pending
Focus Topics of the 2020 IWOAI
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Design of Clinical Trials on Symptom Modification
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Design of Clinical Trials on Structure Modification (DMOADs)
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Design of Novel Image Acquisition Approaches
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Design of Novel Image Segmentation Approaches
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Mechano-Imaging: Design of Studies on Interaction between Mechanics and Joint Structures
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Symptom-Imaging: Design of Studies on Interaction between Symptoms and Joint Structures
Program
Day 1
Wednesday September 09
15:30-16:00
Registration & snacks
PMU, Strubergasse 21, Entree House A (Ground Floor)
16:00
Welcome
Univ. Prof. Dr. med Wolfgang Sperl; Rector, Paracelsus Medical University
Univ. Prof. Dr. med. Jan Pruszak, Chair, Institute of Anatomy & Cell Biology, Paracelsus Medical University
Univ. Prof. Dr. med. Ali Guermazi, President ISOAI
Univ. Prof. Dr. med. Felix Eckstein, Organizer IWOAI 2020
16:15-17:00
Session 1: Symptom-Imaging
Invited Lecture: Frank Roemer
Clinical Outcomes & Translation of Structure Modification to Clinical Benefit
17:00-17:30
1-Tobias Hafner: Effects of collagenase exposure on cartilage functionality – A multiparametric quantitative MRI study (SO)
2-Victoria Racher: Dependence of WOMAC pain on radiographic knee OA status, age, sex, body mass index (BMI), race and contralateral knee pain status (SO)
17:30-18:00
Coffee Break
18:00-18:45
Invited Lecture: Dirk Strunk
Stem Cell Therapy - General Principles and Application to Osteoarthritis
19:00
Dinner: TRUMEREI 9Strubergasse 26)
Day 2
Thursday September 10
09:00-09:45
Session 2: Structure Modification
Invited Lecture: Hans Guehring
Oral Design of Clinical Trials on Structure Modification - Lessons Learned from Sprifermin & Other Programs
9:45-10:45
3-Felix Eckstein: Long-term efficacy and safety of intra-articular Sprifermin in patients with knee osteoarthritis: Results from the 5-year FORWARD study (LO)
4-Henri Deckx: Study design of Roccella: A phase 2 clinical trial with disease-modifying osteoarthritis drug candidate GLPG1972/S201086 (SO)
5-Frank Roemer: Patterns of structural progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype (SO)
10:45-11:15
Coffee Break
11:15-12:00
Session 3: Image Acquisition
Invited Lecture: Neal Bangerter
Design of Novel Image Acquisition Approaches - Current Experience with 7 Tesla
12:00-13:00
6-Daniel Abrar: Detection of early cartilage degeneration in the tibiotalar joint using 3T GAGCEST imaging: A feasibility study (SO)
7-David Fuerst: Superficial cartilage transverse relaxation time (T2) predicts osteoarthritis disease progression – Data from the FNIH Biomarker study of the OAI (SO)
8- Marloes van Mourik: Accuracy of bone density and morphology measurements obtained from high resolution peripheral quantitative CT scans of the knee (SO)
9- Melissa Bevers: The healing of conservatively treated scaphoid fractures assessed by high-resolution peripheral quantitative computed tomography (Poster)
13:00-14:00
Lunch Entree House A (Ground Floor)
14:00-14:45
Session 4: Symptom Modification
Invited Lecture: Christine West
Design of Clinical Trials on Symptom Modification - Lessons Learned from Anti-NGF Programs
14:45-15:30
10-Frank Roemer: Evolution of MRI-defined structural damage after anterior cruciate ligament injury over 5 years: The Kanon study (LO)
11-Peter Mandl: Tendon involvement and its role in hand function and pain in patients with osteoarthritis of the hand (SO)
15:30-16:00
Coffee Break
16:00-18:00
Session 5: Poster Viewing (Multifunction-Room Souterrain)
18:30
Dinner: SEMPRE (Strubergasse 28)
Day 3
Friday September 11
9:00-09:45
Session 6: Image Segmentation
Invited Lecture: Akshay Chaudhari
Novel Image Segmentation Approaches - Lessons Learned from Deep Learning Designs
9:45-11:00
12-Wolfgang Wirth: A deep learning automated segmentation algorithm accurately detects differences in longitudinal cartilage thickness loss – Data from the FNIH biomarkers study of the OAI (LO)
13-David Fuerst: 3D contour registration reveals that location-independent cartilage thickness scores and regional patterns differ between early and late follow-up after ACL rupture (SO)
14-Jana Kemnitz: Automated measurement of local, MRI-based measures of thigh adipose and muscle tissue are highly responsive to bidirectional change in body weight – Data from the OAI (SO)
15-Justus Schock: Artificial intelligence-based automated analysis of alignment in full-leg radiographs (SO)
11:00-11:30
Coffee Break
11:30-12:15
Session 7: Mechano-Imaging
Invited Lecture: Anna-Maria Liphardt
Mechano-Imaging - Imaging Application to Space Flight
12:15-13:15
16-Ali Guermazi: Frequency of osteoarthritis in athletes undergoing MRI at the Olympics in Rio 2016 (LO)
17-Tobias Hafner: Biomechanical Imaging of Proteoglycan-depleted human articular cartilage – A functional MRI study (SO)
18-Rafael Heiss: Effects of sports climbing on cartilage structural composition of the metacarpo-phalangeal and proximal interphalangeal joints as assessed by T2 relaxometry at 7T MRI (SO)
13:15-14:15
Lunch: Entree House A (Ground Floor)
14:15-14:30
Edwin Oei: Invitation to 15th IWOAI 2021 in Rotterdam, The Netherlands
14:30-15:55
Podium Discussion
Drug Development in OA: What are the obstacles?
15:55-16:00
Closing Note: Felix Eckstein & Ali Guermazi
16:00
Drinks: Entree House A & TRUMMEREI
19:00
Dinner: Hangar 7 Bar
Day 4
Saturday September 12
Tour to the Predigtstuhl (1650m)
9:00
Ride with the Predigtstuhlbahn, Germany’s oldest cable car (1927)
from Bad Reichenhall: https://www.predigtstuhlbahn.de/en/home.
Approx. 15 min walk to the mountain restaurant Schlegelmulde.
Excursion to the Hochschlegel and Karkopf for those motivated to hike. Reunite at Mountain Restaurant Schlegelmulde for lunch. Enjoy the afternoon and take the cable car or walk back down to Bad Reichenhall.
Day 5
Sunday September 13
Tour to the Watzmann (2650m)
8:00
For those interested in serous hiking, and pending weather, we will offer climbing the Watzmannhaus at 1930 m altitude starting from Berchtes-gaden, potentially also the Watzmann – Hocheck summit at 2650m altitude.